| Total points scored by both teams | |||
| Pts. | Odds | Pts. | Odds |
| 2-7 | 1000-1 | 43-49 | 3-1 |
| 8-14 | 500-1 | 50-56 | 5-2 |
| 15-21 | 200-1 | 57-63 | 7-2 |
| 22-28 | 40-1 | 64-70 | 7-1 |
| 29-35 | 12-1 | 71-77 | 15-1 |
| 36-42 | 4-1 | 78-up | 25-1 |
| Margin of victory | ||
| New England | Points | New York |
| 6-1 | 1-6 | 6-1 |
| 5-2 | 7-12 | 15-1 |
| 5-2 | 13-18 | 22-1 |
| 4-1 | 19-24 | 50-1 |
| 7-1 | 25-30 | 200-1 |
| 20-1 | 31-36 | 500-1 |
| 25-1 | 37-up | 1000-1 |
| Team to score first | |||
| New England | (-200) | New York | (+170) |
| Will there be one scoreless quarter? | |||
| No | (-370) | Yes | (+280) |
| First scoring play | ||
| New England | Play | New York |
| 3-1 | Field goal | 5-1 |
| 5-2 | TD pass | 7-2 |
| 4-2 | TD run | 7-1 |
| 20-1 | TD other | 30-1 |
| 100-1 | Safety | 100-1 |
| Any score in first 5½ minutes? | |||
| Yes | (-115) | No | (-105) |
| First turnover of game will be? | |||
| Interception | (-160) | Fumble | (+140) |
| Will Patriots convert fourth-down attempt? | |||
| Yes | (-150) | No | (+130) |
| Total rushing yards by each team | |||
| New England | New York | ||
| Over 113½ | (-110) | Over 95½ | (-110) |
| Under 113½ | (-110) | Under 95½ | (-110) |
| What will quarterback throw first? | ||
| Brady | Manning | |
| TD pass | -400 | -140 |
| OR interception | +300 | +120 |
| First-pass completion | -250 | -175 |
| OR incompletion | +210 | +155 |
| Total pass completions by each QB | |||
| Tom Brady | Eli Manning | ||
| Over 26½ | (-120) | Over 20½ | (-110) |
| Under 26½ | (+100) | Under 20½ | (-110) |
| Player to Score First Touchdown | |||
| Player | Odds | Player | Odds |
| Randy Moss | 4-1 | Amani Toomer | 12-1 |
| Wes Welker | 6-1 | Ahmad Bradshaw | 15-1 |
| Laurence Maroney | 7-1 | Donte Stallworth | 15-1 |
| Plaxico Burress | 8-1 | Kevin Boss | 20-1 |
| Brandon Jacobs | 10-1 | Heath Evans | 20-1 |
| Benjamin Watson | 10-1 | Tom Brady | 20-1 |
| Jabar Gaffney | 12-1 | Eli Manning | 25-1 |
| Will a team get 3 unanswered scores? | |||
| Yes | (-240) | No | (+200) |
| Will New York ever have the lead? | |||
| Yes | (-155) | No | (+135) |
| Any successful 2-point conversion? | |||
| No | (-900) | Yes | (+600) |
| Team to have first penalty | |||
| New England | (-105) | New York | (-115) |
| Total QB sacks by both teams | |||
| Under 4 | (-130) | Over 4 | (+110) |
| Will there be a safety? | |||
| No | (-1100) | Yes | (+700) |
| Who will have more today? | ||
| Line | Money | |
| Total points in Super Bowl | -9½ | -110 |
| OR Points by Kobe vs. Washington | +9½ | -110 |
| Total punts in Super Bowl | -1½ | -110 |
| OR Points by Erick Dampier | +1½ | -110 |
| Points by Giants | -1½ | -110 |
| OR Points and assists by Jason Terry vs. Pistons | +1½ | -110 |
| Gross passing yards by Eli Manning | -48½ | -110 |
| OR Total points by Mavs and Pistons | +48½ | -110 |
| Randy Moss receptions | NA | -130 |
| OR Birdies by Tiger Woods in final round at Dubai | NA | +110 |
| To read the money line, use $100 as the base unit. Number of left/top is how much must be wagered to win $100 on the favorite. Number on the right/bottom is how much is returned for a $100 wager on the underdog. | ||